In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy

• DOI: 10.1038/s41467-020-15427-1
• Publication Date: 2020-04-07T10:02:45Z
• Authors: Yannan Liu; Hao Wang; Shanlong Li; Chuanshuang Chen; Li Xu; Ping Huang; Feng Liu; Yue Su; Meiwei Qi; Chunyang Yu; Yongfeng Zhou
• Keywords: Porphyrins; Cell Survival; Polymers; Science; Mice, Nude; 02 engineering and technology; Molecular Dynamics Simulation; Article; Polymerization; Mice; Animals; Humans; Circular Dichroism; Q; Membranes, Artificial; Hyperthermia, Induced; Phototherapy; Rats; MCF-7 Cells; Microscopy, Electron, Scanning; NIH 3T3 Cells; Nanoparticles; Female; 0210 nano-technology; Hydrophobic and Hydrophilic Interactions

Abstract Vesicular photothermal therapy agents (PTAs) are highly desirable in (PTT) for their excellent light-harvesting ability and versatile hollow compartments. However, up to now, the reported vesicular PTAs generally self-assembled from small molecules like liposomes, polymer vesicles have seldom been used as due unsatisfactory conversion efficiency resulting irregular packing of chromophores vesicle membranes. Here we report a nano-sized hyperbranched polyporphyrins with favorable stability extraordinarily high (44.1%), showing great potential imaging-guided PTT tumors through vitro vivo experiments. These properties attributed situ supramolecular polymerization porphyrin units inside membrane into well-organized 1D monofilaments driven by π–π stacking. We believe polymerization-enhanced self-assembly process here will shed new light on design materials structures functions.