Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila

• DOI: 10.1038/s41467-020-16123-w
• Publication Date: 2020-05-08T10:03:33Z
• Authors: Amandine Rambur; Corinne Lours-Calet; Claude Beaudoin; Julio Buñay; Marine Vialat; Vincent Mirouse; Amalia Trousson; Yoan Renaud; Jean-Marc A. Loba...; Silvère Baron; Laurent Morel; Cyrille de Joussi...
• Keywords: Basal (medicine)

Abstract One of the most important but less understood step epithelial tumourigenesis occurs when cells acquire ability to leave their compartment. This phenomenon, described as basal cell extrusion (basal extrusion), represents first tumour invasion. However, due lack adequate in vivo model, implication emblematic signalling pathways such Ras/Mitogen-Activated Protein Kinase (MAPK) and phosphoinositide 3 kinase (PI3K)/protein B (AKT)/mammalian target rapamycin (mTOR) pathways, is scarcely this phenomenon. We have developed a unique model Drosophila accessory gland. There, we demonstrate that both Ras/MAPK PI3K/AKT/mTOR are necessary for extrusion. Furthermore, prostate cancer, show these co-activated. through set up Epidermal Growth Factor Receptor (EGFR) Insulin (InR) dependent autocrine loops, phenomenon that, considering human data, could be relevant cancer.