Evolution of generalist resistance to herbicide mixtures reveals a trade-off in resistance management

• DOI: 10.1038/s41467-020-16896-0
• Publication Date: 2020-06-18T10:04:33Z
• Authors: David Comont; Claudia Lowe; Richard Hull; Laura Crook; Helen L. Hicks; Nawaporn Onkokesung; Roland Beffa; Dylan Z. Childs; Robert Edwards; Robert P. Freckleton; Paul Neve
• Keywords: Pesticide resistance

Abstract Intense selection by pesticides and antibiotics has resulted in a global epidemic of evolved resistance. In agriculture medicine, using mixtures compounds from different classes is widely accepted as optimal resistance management. However, this strategy may promote the evolution more generalist mechanisms. Here we test hypothesis at national scale an economically important agricultural weed: blackgrass ( Alopecurus myosuroides) , for which herbicide major economic issue. Our results reveal that greater use associated with lower levels specialist mechanisms, but higher mechanism implicated enhanced metabolism herbicides diverse modes action. indicate potential evolutionary trade-off management, whereby attempts to reduce traits We contend where mechanisms co-occur, similar trade-offs will be evident, calling into question ubiquity management based on combination therapies.