Iron imaging in myocardial infarction reperfusion injury

• DOI: 10.1038/s41467-020-16923-0
• Publication Date: 2020-06-29T10:02:51Z
• Authors: Brianna F. Moon; Srikant Kamesh Iyer; Eileen Hwuang; Michael P. Solomon; Anya T. Hall; Rishabh Kumar; Nicholas J. Josselyn; Elizabeth M. Higb...; Andrew Tsourkas; Akito Imai; Keitaro Okamoto; Yoshiaki Saito; James J. Pilla; Joseph H. Gorman; Robert C. Gorman; Cory Tschabrunn; Samuel J. Keeney; Estibaliz Castillero; Giovanni Ferrari; Steffen Jockusch; Felix W. Wehrli; Haochang Shou; Victor A. Ferrari; Yuchi Han; Avanti Gulhane; Harold Litt; William Matthai; Walter R. Witschey
• Keywords: Myocardial fibrosis

Abstract Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and failure. Iron is an essential biometal that may have pathologic role in this process. There clinical need for precise noninvasive method detect iron risk stratification patients therapy evaluation. Here, we report magnetic susceptibility imaging large animal model shows infarct paramagnetic shift associated with duration artery occlusion the presence iron. validation techniques used include histology, immunohistochemistry, spectrometry spectroscopy. Further mRNA analysis upregulation ferritin heme oxygenase. While conventional corroborates findings deposition, has improved sensitivity mitigates confounding factors such as edema fibrosis. Myocardial infarction receiving show changes hypokinetic myocardial wall motion microvascular obstruction, demonstrating potential translation.