Bile acids drive the newborn’s gut microbiota maturation

• DOI: 10.1038/s41467-020-17183-8
• Publication Date: 2020-07-23T10:04:12Z
• Authors: N. van Best; U. Rolle-Kampczyk; F. G. Schaap; M. Basic; S. W. M. Olde Damink; A. Bleich; P. H. M. Savelkoul; M. von Bergen; J. Penders; M. W. Hornef
• Keywords: BACTERIAL; Science; DIVERSITY; Administration, Oral; Article; WINDOW; Bile Acids and Salts; 03 medical and health sciences; INTESTINAL MICROBIOTA; Animals; Metabolomics; Phylogeny; Principal Component Analysis; 0303 health sciences; Q; 500; Gastrointestinal Microbiome; 3. Good health; Mice, Inbred C57BL; Kinetics; Lactobacillus; Animals, Newborn; Intestinal Absorption; Liver; info:eu-repo/classification/ddc/500

Abstract Following birth, the neonatal intestine is exposed to maternal and environmental bacteria that successively form a dense highly dynamic intestinal microbiota. Whereas effect of exogenous factors has been extensively investigated, endogenous, host-mediated mechanisms have remained largely unexplored. Concomitantly with microbial colonization, liver undergoes functional transition from hematopoietic organ central metabolic regulation immune surveillance. The aim present study was analyze influence developing hepatic function metabolism on early Here, we report characterization colonization dynamics in murine gastrointestinal tract ( n = 6–10 per age group) using metabolomic profiling combination multivariate analysis. We observed major age-dependent changes identified bile acids as potent drivers microbiota maturation. Consistently, oral administration tauro-cholic acid or β-tauro-murocholic newborn mice 7–14 accelerated postnatal