Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

• DOI: 10.1038/s41467-020-17307-0
• Publication Date: 2020-07-24T10:04:09Z
• Authors: Amine Toubal; Badr Kiaf; Lucie Beaudoin; Lucie Cagninacci; Moez Rhimi; Blandine Fruchet; Jennifer da Silva; Alexandra J. Corbett; Yannick Simoni; Olivier Lantz; Jamie Rossjohn; James McCluskey; Philippe Lesnik; Emmanuelle Maguin; Agnès Lehuen
• Keywords: Dysbiosis

Abstract Obesity is associated with low-grade chronic inflammation promoting insulin-resistance and diabetes. Gut microbiota dysbiosis a consequence as well driver of obesity Mucosal-associated invariant T cells (MAIT) are innate-like expressing semi-invariant cell receptor restricted to the non-classical MHC class I molecule MR1 presenting bacterial ligands. Here we show that during MAIT promote in both adipose tissue ileum, leading insulin resistance impaired glucose lipid metabolism. act by inducing M1 macrophage polarization an MR1-dependent manner gut loss integrity. Both cell-induced alterations contribute metabolic dysfunction. Treatment inhibitory ligand demonstrates its potential strategy against inflammation, disorders.