Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

• DOI: 10.1038/s41467-021-21099-2
• Publication Date: 2021-02-05T11:24:30Z
• Authors: Riyao Yang; Linlin Sun; Ching-Fei Li; Yu-Han Wang; Jun Yao; Hui Li; Meisi Yan; Wei-Chao Chang; Jung-Mao Hsu; Jong-Ho Cha; Jennifer L. Hsu; Cheng-Wei Chou; Xian Sun; Yalan Deng; Chao-Kai Chou; Dihua Yu; Mien-Chie Hung
• Keywords: Crosstalk; Cancer Immunotherapy; Galectin; Galectin-1

The two T cell inhibitory receptors PD-1 and TIM-3 are co-expressed during exhausted differentiation, recent evidence suggests that their crosstalk regulates exhaustion immunotherapy efficacy; however, the molecular mechanism is unclear. Here we show contributes to persistence of