Implication of TIGIT+ human memory B cells in immune regulation

• DOI: 10.1038/s41467-021-21413-y
• Publication Date: 2021-03-09T11:03:14Z
• Authors: Md Mahmudul Hasan; Sumi Sukumaran Nair; Jacqueline G. O’L...; LuAnn Thompson-Sn...; Verah Nyarige; Junwen Wang; Walter Park; Mark Stegall; Raymond Heilman; Goran B. Klintmalm; HyeMee Joo; SangKon Oh
• Keywords: TIGIT; Immunological memory

Abstract Regulatory B cells (Bregs) contribute to immune regulation. However, the mechanisms of action Bregs remain elusive. Here, we report that T cell immunoreceptor with Ig and ITIM domains (TIGIT) expressed on human memory especially CD19 + CD24 hi CD27 CD39 IgD − IgM CD1c is essential for effective Mechanistically, TIGIT controls response by directly acting arresting proinflammatory function dendritic cells, resulting in suppression Th1, Th2, Th17, CXCR5 ICOS while promoting regulatory cells. are also superior other at expressing additional inhibitory molecules, including IL-10, TGFβ1, granzyme B, PD-L1, CD39/CD73, TIM-1. Lack or decrease associated increased donor-specific antibody TFH response, decreased Treg renal liver allograft patients. Therefore, play critical roles