A novel nairovirus associated with acute febrile illness in Hokkaido, Japan

• DOI: 10.1038/s41467-021-25857-0
• Publication Date: 2021-09-20T10:02:53Z
• Authors: Fumihiro Kodama; Hiroki Yamaguchi; Eunsil Park; Kango Tatemoto; Mariko Sashika; Ryo Nakao; Yurino Terauchi; Keita Mizuma; Yasuko Orba; Hiroaki Kariwa; Katsuro Hagiwara; Katsunori Okazaki; Akiko Goto; Rika Komagome; Masahiro Miyoshi; Takuya Ito; Kimiaki Yamano; Kentaro Yoshii; Chiaki Funaki; Mariko Ishizuka; Asako Shigeno; Yukari Itakura; Lesley Bell-Sakyi; Shunji Edagawa; Atsushi Nagasaka; Yoshihiro Sakoda; Hirofumi Sawa; Ken Maeda; Masayuki Saijo; Keita Matsuno
• Keywords: Tick-borne disease; Leukopenia

Abstract The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, 2019 2020, respectively. YEZV phylogenetically grouped Sulina detected Ixodes ricinus ticks Romania. infection has been confirmed seven 2014–2020, four whom were co-infected Borrelia spp. Antibodies to are found wild deer raccoons, RNAs have Hokkaido. this work, demonstrate that highly likely be causative pathogen illness, representing first report an endemic associated potentially transmitted by Japan.