Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil

• DOI: 10.1038/s41467-021-25982-w
• Publication Date: 2021-10-08T00:09:47Z
• Authors: Sue Ann Costa Cle...; Pedro M. Folegatti; Katherine R. W. E...; Lily Yin Weckx; Jeremy Ratcliff; Sagida Bibi; Ana Verena De Alm...; Eveline Pipolo Milan; Ana Pittella; Alexandre V. Schw...; Eduardo Sprinz; Parvinder K. Aley; David Bonsall; Christophe Fraser; Michelle Fuskova; Sarah C. Gilbert; Daniel Jenkin; Sarah Kelly; Simon Kerridge; Teresa Lambe; Natalie G. Marche...; Yama F. Mujadidi; Emma Plested; Maheshi N. Ramasamy; Peter Simmonds; Tanya Golubchik; Merryn Voysey; Andrew J. Pollard; ; David Buck; Angie Green; George MacIntyre-...; Paolo Piazza; John A. Todd; Amy Trebes; Laura Thomson; ; Lygia Accioly Tinoco; Karla Cristina Ma...; Cenusa Almeida; Brian Angus; Beatriz Arns; Laiana Arruda; Renato De Ávila K...; Lucas Henrique Az...; Matheus José Barb...; Brenda Vasconcelo...; Louise Bates; Nancy Bellei; Bruno Boettger; Leandro Bonecker ...; Nina Amanda Borge...; Chrystiane do Nas...; Charlie Brown-O’S...; Daniel Calich Luz; Joao Renato Cardo...; Caroline Scherer ...; Paola Cicconi; Ana Gibertoni Cruz; Debora Cunha; Daniel Marinho Da...; Isabela Garrido D...; Priscila de Arrud...; Bruno Solano de F...; Sergio Carlos Ass...; Maria Isabel de M...; Karolyne Porto De...; Maristela Miyamot...; Milla Dias Sampaio; Janaína Keyla Dio...; Alexander D. Douglas; Suzete Nascimento...; Mujtaba Ghulam Fa...; Shuo Feng; Marcel Catão Ferr...; Marília Miranda F...; Marianne Garcia d...; Fernanda Garcia S...; Tannyth Gomes dos...; Alvaro Henrique G...; Rosana Esteves Ha...; Adrian V. S. Hill; Mimi M. Hou; Bruna Junqueira; Bruna Somavilla K...; Baktash Khozoee; Renan Gustavo Kunst; Jonathan Kwok; Meera Madhavan; José Antônio Main...; Olga Mazur; Angela M. Minassian; Leonardo Motta Ramos; Celia Hatsuko Mya...; Helena Carolina Noal; Natália Nóbrega d...; Rabiullah Noristani; Ana Luiza Perez; Daniel J. Phillips; Priscila Pinheiro; Jéssica Morgana G...; Marie Marcelle Pr...; Isabella Queiroz; Alessandra Ramos ...; Thais Regina Y. C...; Hannah Robinson; Marianna Rocha Jorge; Talita Rochetti; Mariana Bernadi S...; Natalia Zerbinatt...; Fernanda Caldeira...; Mayara Fraga Sant...; Samiullah Seddiqi; Roberta Senger; Robert Shaw; Airanuedida Silva...; Rinn Song; Guilherme G. Sorio; Ricardo Stein; Arabella V. S. St...; Tais Tasqueto Tas...; Cheryl Turner; Tarsila Vieceli; Taiane A. Vieira; João Gabriel Vill...; Marion E. E. Watson; Andy Yao; Rafael Zimmer
• Keywords: 2019-20 coronavirus outbreak; Betacoronavirus

Abstract Several COVID-19 vaccines have shown good efficacy in clinical trials, but there remains uncertainty about the of against different variants. Here, we investigate ChAdOx1 nCoV-19 (AZD1222) symptomatic a post-hoc exploratory analysis Phase 3 randomised trial Brazil (trial registration ISRCTN89951424). Nose and throat swabs were tested by PCR participants. Sequencing genotyping performed to determine lineages SARS-CoV-2 circulating during study. Protection any caused Zeta (P.2) variant was assessed 153 cases with vaccine (VE) 69% (95% CI 55, 78). 49 B.1.1.28 occurred VE 73% (46, 86). The Gamma (P.1) arose later fewer ( N = 18) available for analysis. 64% (−2, 87). provided 95% protection 61%, 99%) hospitalisation due COVID-19. In summary, report that protects emerging variants despite presence spike protein mutation E484K.