Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis

• DOI: 10.1038/s41467-021-27485-0
• Publication Date: 2021-12-09T11:25:36Z
• Authors: Hao Li; Meng Wang; Biao Huang; Su-Wen Zhu; Jun-Jie Zhou; De-Run Chen; Ran Cui; Mingxi Zhang; Zhi-Jun Sun
• Keywords: Abscopal effect

Radiotherapy is an important therapeutic strategy for cancer treatment through direct damage to cells and augmentation of antitumor immune responses. However, the efficacy radiotherapy limited by hypoxia-mediated radioresistance immunosuppression in tumor microenvironment. Here, we construct a stabilized theranostic nanoprobe based on quantum dots emitting near-infrared IIb (NIR-IIb, 1,500-1,700 nm) window modified catalase, arginine-glycine-aspartate peptides poly(ethylene glycol). We demonstrate that nanoprobes effectively aggregate site locate region, thereby realizing precision with few side-effects. In addition, relieve intratumoral hypoxia reduce infiltration immunosuppressive cells. Moreover, promote immunogenic cell death trigger activation dendritic enhance T cell-mediated immunity inhibit metastasis. Collectively, nanoprobe-mediated can boost abscopal effect metastasis prolong survival.