Atomically unveiling the structure-activity relationship of biomacromolecule-metal-organic frameworks symbiotic crystal

• DOI: 10.1038/s41467-022-28615-y
• Publication Date: 2022-02-17T11:02:53Z
• Authors: Linjing Tong; Siming Huang; Yujian Shen; Suya Liu; Xiaomin Ma; Fang Zhu; Guosheng Chen; Gangfeng Ouyang
• Keywords: Microscopy, Electron, Scanning Transmission; Structure-Activity Relationship; X-Ray Absorption Spectroscopy; Science; Q; Cryoelectron Microscopy; Crystallization; 01 natural sciences; Article; Metal-Organic Frameworks; 0104 chemical sciences

Abstract Crystallization of biomacromolecules-metal-organic frameworks (BMOFs) allows for orderly assemble symbiotic hybrids with desirable biological and chemical functions in one voxel. The structure-activity relationship this crystal, however, is still blurred. Here, we directly identify the atomic-level structure BMOFs, using integrated differential phase contrast-scanning transmission electron microscopy, cryo-electron microscopy x-ray absorption fine techniques. We discover an obvious difference nanoarchitecture BMOFs under different crystallization pathways that was previously not seen. In addition, find significantly affects bioactivity BMOFs. This work gives important insight into synthesized scenarios, may act as a guide to engineer next-generation materials excellent functions.