Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19

• DOI: 10.1038/s41467-022-30932-1
• Publication Date: 2022-06-13T10:06:04Z
• Authors: Mirren Charnley; Saba Islam; Guneet K. Bindra; Jeremy Engwirda; Julian Ratcliffe; Jiangtao Zhou; Raffaele Mezzenga; Mark D. Hulett; Kyunghoon Han; Joshua T. Berryman; Nicholas P. Reynolds
• Keywords: Proteome; Amyloid (mycology)

COVID-19 is primarily known as a respiratory disease caused by SARS-CoV-2. However, neurological symptoms such memory loss, sensory confusion, severe headaches, and even stroke are reported in up to 30% of cases can persist after the infection over (long COVID). These thought be produced virus infecting central nervous system, however we don't understand molecular mechanisms triggering them. The effects share similarities neurodegenerative diseases which presence cytotoxic aggregated amyloid protein or peptides common feature. Following hypothesis that some may also follow an etiology identified two from SARS-CoV-2 proteome self-assemble into assemblies. Furthermore, these amyloids were shown highly toxic neuronal cells. We suggest aggregates proteins trigger COVID-19.