Innate immune responses against the fungal pathogen Candida auris

• DOI: 10.1038/s41467-022-31201-x
• Publication Date: 2022-06-21T16:46:48Z
• Authors: Yuanyuan Wang; Yun Zou; Xiaoqing Chen; Hao Li; Zhe Yin; Baocai Zhang; Yongbin Xu; Yiquan Zhang; Rulin Zhang; Xinhua Huang; Wenhui Yang; Chaoyue Xu; Tong Jiang; Qinyu Tang; Zili Zhou; Ying Ji; Yingqi Liu; Lingfei Hu; Jia Zhou; Yao Zhou; Jingjun Zhao; Ningning Liu; Guanghua Huang; Haishuang Chang; Wenxia Fang; Changbin Chen; Dongsheng Zhou
• Keywords: 0301 basic medicine; Antifungal Agents; Science; Q; Candidiasis; Microbial Sensitivity Tests; Candida auris; Article; Immunity, Innate; 3. Good health; 03 medical and health sciences; Candida albicans; Humans; Candida

AbstractCandida auris is a multidrug-resistant human fungal pathogen responsible for nosocomial outbreaks worldwide. Although considerable progress has increased our understanding of the biological and clinical aspects of C. auris, its interaction with the host immune system is only now beginning to be investigated in-depth. Here, we compare the innate immune responses induced by C. auris BJCA001 and Candida albicans SC5314 in vitro and in vivo. Our results indicate that C. auris BJCA001 appears to be less immunoinflammatory than C. albicans SC5314, and this differential response correlates with structural features of the cell wall.