A comprehensive resource for Bordetella genomic epidemiology and biodiversity studies

• DOI: 10.1038/s41467-022-31517-8
• Publication Date: 2022-07-01T16:03:12Z
• Authors: Sébastien Bridel; Valérie Bouchez; Bryan Brancotte; Sofia Hauck; Nathalie Armatys; Annie Landier; Estelle Mühle; Sophie Guillot; Julie Toubiana; Martin C. J. Maiden; Keith A. Jolley; Sylvain Brisse
• Keywords: Multilocus sequence typing; Whooping cough; Bordetella; Bordetella bronchiseptica; Molecular Epidemiology

The genus Bordetella includes bacteria that are found in the environment and/or associated with humans and other animals. A few closely related species, including pertussis, human pathogens cause diseases such as whooping cough. Here, we present a large database of isolates genomes develop genotyping systems for B. pertussis clade. To generate database, merge previously existing databases from Oxford University Institut Pasteur, import public repositories, add 83 newly sequenced bronchiseptica genomes. currently 2582 their provenance data, 2085 ( https://bigsdb.pasteur.fr/bordetella/ ). We use core-genome multilocus sequence typing (cgMLST) to whole well specific schemes define antigenic, virulence macrolide resistance profiles. Phylogenetic analyses allow us redefine evolutionary relationships among known propose potential new species. Our provides an expandable resource environmental clinical isolates, thus facilitating epidemiological research on cough infections.