Multimodal analysis demonstrating the shaping of functional gradients in the marmoset brain

• DOI: 10.1038/s41467-022-34371-w
• Publication Date: 2022-11-03T05:03:38Z
• Authors: Chuanjun Tong; Cirong Liu; Kaiwei Zhang; Binshi Bo; Ying Xia; Hao Yang; Yanqiu Feng; Zhifeng Liang
• Keywords: Functional Imaging

Abstract The discovery of functional gradients introduce a new perspective in understanding the cortical spectrum intrinsic dynamics, as it captures major axes connectivity low-dimensional space. However, how arise and dynamically vary remains poorly understood. In this study, we investigated biological basis using awake resting-state fMRI, retrograde tracing gene expression datasets marmosets. We found marmosets showed sensorimotor-to-visual principal gradient followed by unimodal-to-multimodal gradient, resembling human children. Although strongly constrained structural wirings, were modulated arousal levels. Utilizing reduced model, uncovered opposing effects on dynamics (inverted U-shape) neuromodulatory input (U-shape) with fluctuations, dissected contribution individual receptors. This study provides insights into revealing interaction between ascending system.