Lipidomic signatures align with inflammatory patterns and outcomes in critical illness

• DOI: 10.1038/s41467-022-34420-4
• Publication Date: 2022-11-10T05:05:35Z
• Authors: Junru Wu; Anthony Cyr; Danielle S. Gruen; Tyler C. Lovelace; Panayiotis V. Benos; Jishnu Das; Upendra K. Kar; Tianmeng Chen; Francis X. Guyette; Mark H. Yazer; Brian J. Daley; Richard S. Miller; Brian G. Harbrecht; Jeffrey A. Claridge; Herb A. Phelan; Brian S. Zuckerbraun; Matthew D. Neal; Pär I. Johansson; Jakob Stensballe; Rami A. Namas; Yoram Vodovotz; Jason L. Sperry; Timothy R. Billiar; ; Mazen S. Zenati; Joshua B. Brown; Darrell J. Triulzi; Barbara J. Early ...; Peter W. Adams; Louis H. Alarcon; Clifton W. Callaway; Raquel M. Forsythe; Donald M. Yealy; Andrew B. Peitzman; Meghan L. Buck; Ashley M. Ryman; Elizabeth A. Gimbel; Erin G. Gilchrist; Meghan Buhay; Chung-Chou H. Chang; Victor B. Talisa; Tianyuan Xu; Kyle Kalloway; Andrew Yates; Susan Rawn; Judith M. Jenkins; Laura S. Trachten...; Randi K. Eden; Joanne Fraifogl; Craig Bates; Christina Howard; Cari Stebbins; William R. Witham; Cathy McNeill; A. Tyler. Putnam; Amy Snyder; Jason Ropp; Therese M. Duane; Celeste Caliman; Mieshia Beamon
• Keywords: Inflammation; Science; Critical Illness; Q; Lipidomics; Humans; COVID-19; Article; Biomarkers; 3. Good health

Alterations in lipid metabolism have the potential to be markers as well drivers of pathobiology acute critical illness. Here, we took advantage temporal precision offered by trauma a common cause illness identify dynamic patterns circulating lipidome critically ill humans. The major findings include an early loss all classes lipids followed delayed and selective lipogenesis patients destined remain ill. previously reported survival benefit thawed plasma administration was associated with preserved levels that related favorable changes coagulation inflammation biomarkers causal modelling. Phosphatidylethanolamines (PE) were elevated persistent PE prognostic for worse outcomes not only but also severe COVID-19 patients. Here show rise systemic feature