An integrated resource for functional and structural connectivity of the marmoset brain

• DOI: 10.1038/s41467-022-35197-2
• Publication Date: 2022-12-01T18:40:26Z
• Authors: Xiaoguang Tian; Yuyan Chen; Piotr Majka; Diego Szczupak; Yonatan Sanz Perl; Cecil Chern-Chyi Yen; Chuanjun Tong; Furui Feng; Haiteng Jiang; Daniel Glen; Gustavo Deco; Marcello G. P. Rosa; Afonso C. Silva; Zhifeng Liang; Cirong Liu
• Keywords: 0303 health sciences; Network models; Science; Q; Brain; Neuroimaging; Callithrix; Neural circuits; Functional Connectivity; Article; Marmoset; Structural Connectivity; 03 medical and health sciences; Diffusion Magnetic Resonance Imaging; 0302 clinical medicine; https://purl.org/becyt/ford/3.1; Animals; Computer Simulation; https://purl.org/becyt/ford/3

Abstract Comprehensive integration of structural and functional connectivity data is required to model brain functions accurately. While resources for studying the non-human primate brains already exist, their with has remained unavailable. Here we present a comprehensive resource that integrates most extensive awake marmoset resting-state fMRI available date (39 monkeys, 710 runs, 12117 mins) previously published cellular-level neuronal tracing (52 143 injections) multi-resolution diffusion MRI datasets. The combination these allowed us (1) map fine-detailed networks cortical parcellations, (2) develop deep-learning-based parcellation generator preserves topographical organization reflects individual variabilities, (3) investigate basis underlying by computational modeling. This will enable modeling structure-function relationships facilitate future comparative translational studies brains.