Neural precursor cells tune striatal connectivity through the release of IGFBPL1

• DOI: 10.1038/s41467-022-35341-y
• Publication Date: 2022-12-08T17:03:14Z
• Authors: Erica Butti; Stefano Cattaneo; Marco Bacigaluppi; Marco Cambiaghi; Giulia Maria Scotti; Elena Brambilla; Francesca Ruffini; Giacomo Sferruzza; Maddalena Ripamonti; Fabio Simeoni; Laura Cacciaguerra; Aurora Zanghì; Angelo Quattrini; Riccardo Fesce; Paola Panina-Bord...; Francesca Giannese; Davide Cittaro; Tanja Kuhlmann; Patrizia D’Adamo; Maria Assunta Rocca; Stefano Taverna; Gianvito Martino
• Keywords: Medium spiny neuron

Abstract The adult brain retains over life endogenous neural stem/precursor cells (eNPCs) within the subventricular zone (SVZ). Whether or not these exert physiological functions is still unclear. In present work, we provide evidence that SVZ-eNPCs tune structural, electrophysiological, and behavioural aspects of striatal function via secretion insulin-like growth factor binding protein-like 1 (IGFBPL1). mice, selective ablation abrogation IGFBPL1 determined an impairment medium spiny neuron morphology, a higher failure rate in GABAergic transmission mediated by fast-spiking interneurons, striatum-related dysfunctions. We also found expression human SVZ, foetal induced-pluripotent stem cell-derived NPCs. Finally, significant correlation between SVZ damage, reduction striatum volume, information processing speed neurological patients. Our results highlight role supporting cognitive regulating neuronal activity.