Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases

• DOI: 10.1038/s41467-023-41783-9
• Publication Date: 2023-10-02T16:02:13Z
• Authors: Peisen Zhang; Junwei Cheng; Yijie Lu; Ni Zhang; Xiaoai Wu; Hua Lin; Wei Li; Jian Wang; Mitchell A. Winnik; Zhihua Gan; Yi Hou
• Keywords: Cerebrovascular Disorders; Swine; Science; Q; Animals; Contrast Media; Magnetic Resonance Imaging; Article; Magnetic Resonance Angiography; 3. Good health; Chelating Agents

AbstractMagnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are limited by their rapid vascular extravasation. Herein, we report a hypersensitive MR angiography strategy based on interlocking stratagem of zwitterionic Gd-chelate contrast agents (PAA-Gd). The longitudinal molar relaxivity of PAA-Gd was 4.6-times higher than that of individual Gd-chelates as well as appropriate blood half-life (73.8 min) and low immunogenicity, enabling sophisticated micro-vessels angiography with a resolution at the order of hundred micrometers. A series of animal models of cardiac-cerebrovascular diseases have been built for imaging studies on a 7.0 T MRI scanner, while the clinical translation potential of PAA-Gd has been evaluated on swine on a 3.0 T clinical MRI scanner. The current studies offer a promising strategy for precise diagnosis of vascular diseases.