Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways

• DOI: 10.1038/s41467-023-42005-y
• Publication Date: 2023-10-27T11:03:21Z
• Authors: Xu Lin; Hong-Mei Xiao; Hui-Min Liu; Wan-Qiang Lv; Jonathan Greenbaum; Rui Gong; Qiang Zhang; Yuan-Cheng Chen; Cheng Peng; Xue-Juan Xu; Dao-Yan Pan; Zhi Chen; Zhang-Fang Li; Rou Zhou; Xia-Fang Wang; Jun-Min Lu; Zeng-Xin Ao; Yu-Qian Song; Yin-Hua Zhang; Kuan-Jui Su; Xiang-He Meng; Chang-Li Ge; Feng-Ye Lv; Zhe Luo; Xing-Ming Shi; Qi Zhao; Bo-Yi Guo; Neng-Jun Yi; Hui Shen; Christopher J. Pa...; Jie Shen; Hong-Wen Deng
• Keywords: Bone remodeling

Abstract Although the gut microbiota has been reported to influence osteoporosis risk, individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese cohort of peri-/post-menopausal women with metagenomics/targeted metabolomics/whole-genome sequencing identify novel microbiome-related biomarkers for bone health. Bacteroides vulgatus was found be negatively associated mineral density (BMD), which validated US white people. Serum valeric acid (VA), derived metabolite, positively BMD causally downregulated by B. . Ovariectomized mice fed demonstrated increased resorption poorer micro-structure, while those VA reduced better micro-structure. suppressed RELA protein production (pro-inflammatory), enhanced IL10 mRNA expression (anti-inflammatory), leading maturation osteoclast-like cells osteoblasts vitro. The findings suggest that may represent promising targets prevention/treatment.