Fatty acid desaturation and lipoxygenase pathways support trained immunity

• DOI: 10.1038/s41467-023-43315-x
• Publication Date: 2023-11-15T15:02:19Z
• Authors: Anaísa V. Ferreira; Juan Carlos Alarc...; Jorge Domínguez-A...; Özlem Bulut; Gizem Kilic; Priya A. Debisarun; Rutger J. Röring; Hatice N. Özhan; Eva Terschlüsen; Athanasios Ziogas; Sarantos Kostidis; Yassene Mohammed; Vasiliki Matzaraki; George Renieris; Evangelos J. Giam...; Mihai G. Netea; Martin Giera
• Keywords: Trained Immunity; Radboudumc 4: lnfectious Diseases and Global Health Internal Medicine; Science; Q; BCG Vaccine; Radboud University Medical Center; Humans; Lipoxygenases; Lipids; Radboudumc 4: lnfectious Diseases and Global Health Medical Microbiology; Article; Immunity, Innate; 3. Good health

Abstract Infections and vaccines can induce enhanced long-term responses in innate immune cells, establishing an immunological memory termed trained immunity . Here, we show that monocytes with a phenotype, due to exposure the Bacillus Calmette-Guérin (BCG) vaccine, are characterized by increased biosynthesis of different lipid mediators (LM) derived from long-chain polyunsaturated fatty acids (PUFA). Pharmacological genetic approaches PUFA synthesis lipoxygenase-derived LM essential for BCG-induced human monocytes. Furthermore, products 12-lipoxygenase activity increase healthy individuals after BCG vaccination. Grasping underscoring metabolic pathways contributes our understanding may help identify therapeutic tools targets modulation responses.