Causes of death among people living with metastatic cancer

• DOI: 10.1038/s41467-024-45307-x
• Publication Date: 2024-02-19T18:02:11Z
• Authors: Kyle Mani; Daxuan Deng; Christine Lin; Ming Wang; Melinda L. Hsu; Nicholas G. Zaorsky
• Keywords: Male; Heart Diseases; Science; Cancer screening ; Metastasis ; Cancer epidemiology; Q; Breast Neoplasms; Article; Causality; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Cause of Death; Humans

Abstract Studying survivorship and causes of death in patients with advanced or metastatic cancer remains an important task. We characterize the among cancer, across 13 types 25 non-cancer predict risk after diagnosis from diagnosed versus other (e.g., stroke, heart disease, etc.). Among 1,030,937 US (1992–2019) survivors, 82.6% (n = 688,529) died due to while 17.4% 145,006) competing causes. Patients lung, pancreas, esophagus, stomach tumors are most likely die their those prostate breast have lowest likelihood. The median survival time living metastases is 10 months; our Fine Gray model predicts 1 year area under receiver operating characteristic curve 0.754 (95% CI [0.754, 0.754]). Leading deaths disease (32.4%), chronic obstructive pulmonary (7.9%), cerebrovascular (6.1%), infection (4.1%).