Rapid meiotic prophase chromosome movements in Arabidopsis thaliana are linked to essential reorganization at the nuclear envelope

• DOI: 10.1038/s41467-024-50169-4
• Publication Date: 2024-07-16T10:08:28Z
• Authors: Laurence Cromer; Mariana Tiscareno...; Sandrine Lefranc; Aurélie Chambon; Aurélie Hurel; Manon Brogniez; Julie Guérin; Ivan Le Masson; Gabriele Adam; Delphine Charif; Philippe Andrey; Mathilde Grelon
• Keywords: 0301 basic medicine; Nuclear Envelope; Arabidopsis Proteins; [SDV]Life Sciences [q-bio]; Science; Q; Centromere; Arabidopsis; Nuclear Proteins; Telomere; Prophase; Article; Chromosomes, Plant; Meiosis; 03 medical and health sciences; Meiotic Prophase I

Abstract Meiotic rapid prophase chromosome movements (RPMs) require connections between the chromosomes and cytoskeleton, involving SUN (Sad1/UNC-84)-domain-containing proteins at inner nuclear envelope (NE). RPMs remain significantly understudied in plants, with respect to their importance regulation of meiosis. Here, we demonstrate that Arabidopsis thaliana meiotic centromeres undergo (up 500 nm/s) uncoordinated during zygotene pachytene stages. These centromere are not affected by altered organization recombination but abolished double mutant sun1 sun2 . We also document changes dynamics nucleus transition from leptotene zygotene, including telomere attachment SUN-enriched NE domains, bouquet formation, nucleolus displacement, all which were defective results establish A. as a model species for studying functional implications mechanistic conservation telomere-led plants.