Adaptive laboratory evolution recruits the promiscuity of succinate semialdehyde dehydrogenase to repair different metabolic deficiencies

• DOI: 10.1038/s41467-024-53156-x
• Publication Date: 2024-10-15T21:01:52Z
• Authors: Hai He; Paul A. Gómez-Cor...; Jan Zarzycki; Sebastian Barthel; Jörg Kahnt; Peter Claus; Moritz Klein; Melanie Klose; Valérie de Crécy-...; Daniel Schindler; Nicole Paczia; Timo Glatter; Tobias J. Erb
• Keywords: Metabolic pathway

Promiscuous enzymes often serve as the starting point for evolution of novel functions. Yet, extent to which promiscuity an individual enzyme can be harnessed several times independently different purposes during is poorly reported. Here, we present a case study illustrating how NAD(P)