Comparative transcriptomics in serial organs uncovers early and pan-organ developmental changes associated with organ-specific morphological adaptation

• DOI: 10.1038/s41467-025-55826-w
• Publication Date: 2025-01-17T13:40:26Z
• Authors: Marie Sémon; Marion Mouginot; Manon Peltier; Claudine Corneloup; Philippe Veber; Laurent Guéguen; Sophie Pantalacci
• Keywords: Body plan; Organ system

Mice have evolved a new dental plan with two additional cusps on the upper molar, while hamsters were retaining ancestral plan. By comparing dynamics of molar development transcriptome time series, we found at least three early changes in mouse development. Together, they redirect spatio-temporal to ultimately form cusps. The lower has undergone much more limited phenotypic evolution. Nevertheless, its developmental trajectory as that and co-evolved it. Among coevolving changes, some are clearly involved phenotype. We similar level coevolution bat limbs. In conclusion, our study reveals how serial organ morphology adapted through organ-specific expected, but also shared effects final This highlights important role system drift one accommodate adaptation another.