Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose–response effects on glucose metabolism in human subjects with metabolic syndrome

• DOI: 10.1038/s41522-020-0127-0
• Publication Date: 2020-03-27T11:03:11Z
• Authors: Pim W. Gilijamse; Annick V. Hartstra; Evgeni Levin; Koen Wortelboer; Mireille J. Serlie; Mariette T. Acker...; Hilde Herrema; Aart J. Nederveen; Sultan Imangaliyev; Steven Aalvink; Morton Sommer; Han Levels; Erik S. G. Stroes; Albert K. Groen; Marleen Kemper; Willem M. de Vos; Max Nieuwdorp; Andrei Prodan
• Keywords: Dysbiosis; Carbohydrate Metabolism

Abstract Dysbiosis of the intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality humans is scarce. We performed a phase I/II dose-finding and safety study on effect oral intake anaerobic butyrogenic strain Anaerobutyricum soehngenii glucose metabolism 24 subjects with metabolic syndrome. found that treatment A. was safe observed significant correlation between measured fecal abundance administered improvement peripheral sensitivity after 4 weeks treatment. This accompanied by an altered composition change bile acid metabolism. Finally, we show response upon administration (defined as improved intake) dependent at baseline. These data are promising, but additional studies needed to reproduce our findings investigate long-term effects, well other modes delivery.