Structures shed light on prostanoid signaling

• DOI: 10.1038/s41589-018-0178-1
• Publication Date: 2018-11-23T11:15:47Z
• Authors: Kaspar Hollenstein
• Keywords: Prostanoid

Prostanoids signal through G-protein-coupled receptors to regulate diverse physiological processes. Structures of three prostanoid receptors in inactive and active conformations now uncover the molecular determinants of ligand recognition and receptor activation and offer new opportunities for drug discovery.