Bacterial alterations in salivary microbiota and their association in oral cancer

• DOI: 10.1038/s41598-017-16418-x
• Publication Date: 2017-11-22T16:42:28Z
• Authors: Wei-Hsiang Lee; Hui-Mei Chen; Shun-Fa Yang; Chao Liang; Chih-Yu Peng; Feng-Mao Lin; Lo-Lin Tsai; Buor-Chang Wu; Chung-Han Hsin; Chun-Yi Chuang; Ting Yang; Tzu-Ling Yang; Shinn-Ying Ho; Wen-Liang Chen; Kwo-Chang Ueng; Hsien-Da Huang; Chien-Ning Huang; Yuh-Jyh Jong
• Keywords: Peptostreptococcus

Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of oral cavity and fourth leading malignancy cause cancer-related death in male population Taiwan. Most cases are detected at advanced stages, resulting poor prognosis. Therefore, improved detection early health disorders indispensable. The involvement bacteria inflammation their association with OSCC progression provide a feasible target for diagnosis. Due to nature neoplasms, diagnosis epithelial precursor lesions relatively easy compared that other types cancer. However, transition from an lesion cancer slow requires further continuous follow-up. In this study, we investigated microbiota differences between normal individuals, patients, patients different lifestyle habits, such as betel chewing smoking, using next-generation sequencing. Overall, microbiome compositions five genera, Bacillus , Enterococcus Parvimonas Peptostreptococcus Slackia revealed significant correlated classification into two clusters. These composition changes might have potential constitute biomarker help monitoring carcinogenesis