Fibroblast growth factor-21 as a novel metabolic factor for regulating thrombotic homeostasis

• DOI: 10.1038/s41598-021-00906-2
• Publication Date: 2022-01-10T11:04:32Z
• Authors: Shuai Li; Haibo Jia; Zhihang Liu; Nan Wang; Xiaochen Guo; Muhua Cao; Fang Fang; Jiarui Yang; Junyan Li; Qi He; Rui Guo; Teng Zhang; Kai Kang; Zongbao Wang; Shijie Liu; Yukai Cao; Xinghao Jiang; Guiping Ren; Kai Wang; Bo Yu; Wei Xiao; Deshan Li
• Keywords: Plasminogen activator inhibitor-1; FGF21

Abstract Fibroblast growth factor-21 (FGF-21) performs a wide range of biological functions in organisms. Here, we report for the first time that FGF-21 suppresses thrombus formation with no notable risk bleeding. Prophylactic and therapeutic administration significantly improved degree vascular stenosis reduced area, volume burden. We determined antithrombotic mechanism FGF-21, demonstrating exhibits an anticoagulant effect by inhibiting expression activity factor VII (FVII). exerts antiplatelet platelet activation. enhances fibrinolysis promoting tissue plasminogen activator (tPA) activation, while inhibitor 1 (PAI-1) further found mediated activation tPA PAI-1 regulating ERK1/2 TGF-β/Smad2 pathways, respectively. In addition, inhibits inflammatory factors thrombosis NF-κB pathway.