Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial

• DOI: 10.1038/s41598-021-03802-x
• Publication Date: 2022-01-10T11:04:32Z
• Authors: Aleksandar Radosevic; Rita Quesada; Clara Serlavos; Juan Sánchez; Ander Zugazaga; Ana Sierra; Susana Coll; Marcos Busto; Guadalupe Aguilar; Daniel Flores; Javier Arce; José María Maiques; Montserrat Garcia...; José Antonio Carrion; Laura Visa; María Villamonte; Eva Pueyo; Enrique Berjano; Macarena Trujillo; Patricia Sánchez-...; Luís Grande; Fernando Burdio
• Keywords: Microwave ablation; Clinical endpoint; Ablation zone; Ablative case

Abstract Microwave (MWA) and radiofrequency ablation (RFA) are main ablative techniques for hepatocellular carcinoma (HCC) colorectal liver metastasis (MT). This randomized phase 2 clinical trial compares the effectiveness of MWA RFA as well morphology corresponding zones. HCC MT patients with 1.5–4 cm tumors, suitable ablation, were into or Groups. The primary endpoint was short-to-long diameter ratio zone (SLR). Primary technical success (TS) a cumulative local tumor progression (LTP) after median 2-year follow-up compared. Between June 2015 April 2020, 82 randomly assigned (41 per group). For per-protocol analysis, five excluded. created larger zones than ( p = 0.036) although without differences in SLR (0.5 both groups, 0.229). TS achieved 98% (46/47) 90% (45/50) 0.108), LTP observed 21% (10/47) vs. 12% (6/50) (OR 1.9 [95% CI 0.66–5.3], 0.238) tumors Group, respectively. Major complications found 5 cases (11%) (4%), statistical significance. show similar SLR, safety between 1.5 4 cm.