Extracellular vesicles isolated from milk can improve gut barrier dysfunction induced by malnutrition

• DOI: 10.1038/s41598-021-86920-w
• Publication Date: 2021-04-07T10:12:21Z
• Authors: Mohamed Karim Mag...; Bo Li; Lijun Chi; Catriona Ling; Abderrahim Benmoussa; Patrick Provost; Andrea C. Postmus; Abdirahman Abdi; Agostino Pierro; Celine Bourdon; Robert H. J. Bandsma
• Keywords: Extracellular Vesicles

Abstract Malnutrition impacts approximately 50 million children worldwide and is linked to 45% of global mortality in below the age five. Severe acute malnutrition (SAM) associated with intestinal barrier breakdown epithelial atrophy. Extracellular vesicles including exosomes (EVs; 30–150 nm) can travel distant target cells through biofluids milk. Since milk-derived EVs are known induce stem cell proliferation, this study aimed examine their potential efficacy improving malnutrition-induced atrophy mucosa dysfunction. Mice were fed either a control (18%) or low protein (1%) diet for 14 days malnutrition. From day 10 14, they received bovine milk gavage sacrificed on 15, 4 h after Fluorescein Isothiocyanate (FITC) dose. Tissue blood collected histological function analyses. developed villus Despite continued feeding, EV treatment improved permeability, architecture cellular proliferation. Our results suggest that enriched from should be further explored as valuable adjuvant therapy standard clinical management malnourished high risk morbidity mortality.