Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer

• DOI: 10.1038/s41598-021-93485-1
• Publication Date: 2021-07-07T10:04:51Z
• Authors: Rachelle P. Mendoza; Tahmineh Haidary; Elmer Gabutan; Ying Yin Zhou; Zaheer Bukhari; Courtney Connelly; Wen-Ching Lee; Yi-Chun Lee; Raj Wadgaonkar; Raag Agrawal; M. A. Haseeb; Raavi Gupta
• Keywords: Adult; Genotype; Science; Uterine Cervical Neoplasms; Article; Immunophenotyping; 03 medical and health sciences; 0302 clinical medicine; Recurrence; Biomarkers, Tumor; Humans; Public Health Surveillance; Papillomavirus Vaccines; Papillomaviridae; Aged; Neoplasm Staging; Coinfection; Q; Papillomavirus Infections; R; Middle Aged; Immunohistochemistry; 3. Good health; Black or African American; Medicine; Female; Disease Susceptibility; Neoplasm Grading

Abstract We studied the incidence of HPV genotypes in mostly Black women with cervical carcinoma and correlated histopathologic tumor characteristics, immune markers clinical data survival. Disease-free survival (DFS) overall (OS) were recorded for 60 months post-diagnosis. Fifty four (90%) patients 36 (60%) < 55 years age. Of 40 typeable genotypes, 10 (25%) had 16/18 30 (75%) one non-16/18 20 (50%) 7 (35, 39, 51, 53, 56, 59 68) that are not included nonavalent vaccine. Mixed infections (≥ 2 types) found 11/40 (27.5%) patients. Patients infected including most common genotype, 35, significantly shorter DFS OS. PD-L1 (p = 0.003), MMR expression 0.01), stage 0.048), histologic grade 0.015) mixed infection 0.026) independent predictors DFS. A remarkably high proportion cancer cells our expressed which opens possibility use checkpoint inhibitors to treat these cancers. Exclusion from vaccine exacerbates mortality underserved