Phylogeography and genomic epidemiology of SARS-CoV-2 in Italy and Europe with newly characterized Italian genomes between February-June 2020

• DOI: 10.1038/s41598-022-09738-0
• Publication Date: 2022-04-06T06:08:13Z
• Authors: Alessia Lai; Annalisa Bergna; Stefano Toppo; Marina Morganti; Stefano Menzo; Valeria Ghisetti; Bianca Bruzzone; Mauro Codeluppi; Vito Fiore; Emmanuele Venanzi...; Guido Antonelli; Loredana Sarmati; Gaetano Brindicci; Annapaola Callegaro; Caterina Sagnelli; Daniela Francisci; Ilaria Vicenti; Arianna Miola; Giovanni Tonon; Daniela Cirillo; Ilaria Menozzi; Sara Caucci; Francesco Cerutti; Andrea Orsi; Roberta Schiavo; Sergio Babudieri; Giuseppe Nunnari; Claudio M. Mastro...; Massimo Andreoni; Laura Monno; Davide Guarneri; Nicola Coppola; Andrea Crisanti; Massimo Galli; Gianguglielmo Zeh...; ; Claudia Balotta; Carla della Ventura; Marco Schiuma; Enrico Lavezzo; Paolo Fontana; Luca Bianco; Luigi Bertolotti; Laura Manuto; Marco Grazioli; Federico Bianca; Claudia Del Vecchio; Elisa Franchin; Francesco Onelia; Andrea Spitaleri; Francesca Saluzzo; Giovanni Lorenzin; Stefano Pongolini; Erika Scaltriti; Laura Soliani; Patrizia Bagnarelli; Chiara Turchi; Valerio Onofri; Filomena Melchionda; Adriano Tagliabracci; Elisa Burdino; Maria Grazia Milia; Patrizia Caligiuri; Vanessa De Pace; Valentina Ricucci; Alexander Domnich; Simona Boccotti; Leoni Maria Cristina; Giuliana Lo Cascio; Salvatore Rubino; Vincenzo Lai; Giulia Rocca; Rosalba Govoni; Giuseppe Mancuso; Roberta Campagna; Laura Mazzuti; Giuseppe Oliveto; Ombretta Turriziani; Laura Campogiani; Mirko Compagno; Luigi Coppola; Angela Maria Anto...; Giuseppe De Simone; Andrea Di Lorenzo; Ludovica Ferrari; Marco Iannetta; Vincenzo Malagnino; Tiziana Mulas; Benedetta Rossi; Ilaria Spalliera; Simona Tedde; Elisabetta Teti; Pietro Vitale; Marta Zordan; Eugenio Milano; Antonella Lagioia; Rosa Gallitelli; Mario Starace; Carmine Minichini; Alessia Di Fraia; Maddalena Schioppa; Rita Greco; Anna Gidari; Maurizio Zazzi; Filippo Dragoni; Laura Li Puma; Silvia Ronchiadin; Luigi Ruggerone; Dario Russignaga
• Keywords: Lineage (genetic); Pandemic; Northern italy

The aims of this study were to characterize new SARS-CoV-2 genomes sampled all over Italy and reconstruct the origin evolutionary dynamics in Europe between February June 2020. cluster analysis showed only small clusters including < 80 Italian isolates, while most strains intermixed whole tree. Pure observed mainly after lockdown distancing measures adopted. Lineage B B.1 spread late January early 2020, from China Veneto Lombardy, respectively. B.1.1 (20B) probably evolved within central south regions, European countries. lineage B.1.1.1 (20D) developed other countries entering second half March remained localized Piedmont until In conclusion, limitations phylogeographical reconstruction, estimated ancestral scenario suggests an important role widespread diffusion D614G variant phase pandemic more dispersed exchanges involving several