Tumor blood flow and apparent diffusion coefficient histogram analysis for differentiating malignant salivary tumors from pleomorphic adenomas and Warthin’s tumors

• DOI: 10.1038/s41598-022-09968-2
• Publication Date: 2022-04-08T10:11:21Z
• Authors: Fumine Tanaka; Maki Umino; Masayuki Maeda; Ryohei Nakayama; Katsuhiro Inoue; Ryota Kogue; Makoto Obara; Hajime Sakuma
• Keywords: Coefficient of variation

Abstract We aimed to assess the combined diagnostic value of apparent diffusion coefficient (ADC) and tumor blood flow (TBF) obtained by pseudocontinuous arterial spin labeling (pCASL) for differentiating malignant tumors (MTs) in salivary glands from pleomorphic adenomas (PAs) Warthin’s (WTs). used pCASL imaging ADC map evaluate 65 patients, including 16 with MT, 30 PA, 19 WT. evaluated all histogram analyses compared various characteristics one-way analysis variance followed Tukey post-hoc tests. Diagnostic performance was receiver operating characteristic (ROC) curve analysis. There were significant differences mean, 50th, 75th, 90th percentiles TBF among types, mean TBFs (mL/100 g/min) between MTs (57.47 ± 35.14) PAs (29.88 22.53, p = 0.039) WTs (119.31 50.11, < 0.001), as well ADCs (× 10 −3 mm 2 /s) (1.08 0.28) (1.60 0.34, but not (0.87 0.23, 0.117). In ROC analysis, highest areas under curves (AUCs) achieved 10th 25th (AUC 0.885) 50th percentile 0.855) WTs. The AUCs TBF, ADC, combination 0.850, 0.885, 0.950 differentiation 0.855, 0.814, 0.905 differentiation, respectively. may help differentiate gland