Association between cholesterol levels and dementia risk according to the presence of diabetes and statin use: a nationwide cohort study

• DOI: 10.1038/s41598-022-24153-1
• Publication Date: 2022-11-12T11:03:04Z
• Authors: You-Bin Lee; Min Young Kim; Kyungdo Han; Bongsung Kim; Jiyun Park; Gyuri Kim; Kyu Yeon Hur; Jae Hyeon Kim; Sang-Man Jin
• Keywords: Quartile

Abstract We explored the association between cholesterol levels and dementia risk according to presence of diabetes statin use. In this population-based longitudinal cohort study, Korean National Health Insurance Service datasets (2002–2017) were used. Among individuals aged ≥ 40 years who underwent health examinations in 2009 (N = 6,883,494), hazard was evaluated levels. During a median 8.33 years, 263,185 cases detected. non-users with or without diabetes, hazards all-cause highest for those lowest quartile quintile low-density lipoprotein-cholesterol (LDL-C) level, showing an inverted J-shaped relationship. users advance LDL-C group associated increase dementia. even very low level not increased Although there seemingly paradoxical non-users, trend observed is likely be clinically relevant. Rather, users, regardless diabetes.