DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

• DOI: 10.1038/s42003-020-01469-0
• Publication Date: 2021-02-03T11:10:36Z
• Authors: Vanessa Lakis; Rita T. Lawlor; Felicity Newell; Ann-Marie Patch; Andrea Mafficini; Anguraj Sadanandam; Lambros T. Koufar...; Rebecca L. Johnston; Conrad Leonard; Scott Wood; Borislav Rusev; Vincenzo Corbo; Claudio Luchini; Sara Cingarlini; Luca Landoni; Roberto Salvia; Michele Milella; David Chang; Peter Bailey; Nigel B. Jamieson; Fraser Duthie; Marie-Claude Gingras; Donna M. Muzny; David A. Wheeler; Richard A. Gibbs; Massimo Milione; ; ; Lorraine A. Chant...; Paul Timpson; Angela Chou; Marina Pajic; Angela Murphy; Tanya Dwarte; David Hermann; Claire Vennin; Thomas R. Cox; Brooke Pereira; Shona Ritchie; Daniel A. Reed; Cecilia R. Chambers; Xanthe Metcalf; Max Nobis; ; Pamela Mukhopadhyay; Venkateswar Addala; Stephen Kazakoff; Oliver Holmes; Qinying Xu; ; Oliver Hofmann; ; Jaswinder S. Samra; Nick Pavlakis; Jennifer Arena; Hilda A. High; ; Ray Asghari; Neil D. Merrett; Darren Pavey; Amitabha Das; ; Peter H. Cosman; Kasim Ismail; Chelsie O’Connnor; ; Alina Stoita; David Williams; Allan Spigellman; ; Vincent W. Lam; Duncan McLeod; Judy Kirk; ; James G. Kench; Peter Grimison; Charbel Sandroussi; Annabel Goodwin; ; R. Scott Mead; Katherine Tucker; Lesley Andrews; ; Michael Texler; Cindy Forest; Mo Ballal; David R. Fletcher; ; Nikolajs Zeps; ; Nan Q. Nguyen; Andrew R. Ruszkie...; Chris Worthley; ; John Chen; Mark E. Brooke-Smith; Virginia Papangelis; ; Andrew D. Clouston; ; Andrew P. Barbour; Thomas J. O’Rourke; Jonathan W. Fawcett; Kellee Slater; Michael Hatzifotis; Peter Hodgkinson; ; Mehrdad Nikfarjam; ; James R. Eshleman; Ralph H. Hruban; Christopher L. Wo...; ; Judith Dixon; ; Maria Scardoni; Claudio Bassi; Sonia Grimaldi; Cinzia Cantù; Giada Bonizzato; Samantha Bersani; Davide Antonello; Liliana Piredda; Nicola Sperandio; Stefano Barbi; Paola Merlini; Paolo Pederzoli; Jaswinder S. Samra; Anthony J. Gill; Amber L. Johns; John V. Pearson; Andrew V. Biankin; Sean M. Grimmond; Nicola Waddell; Katia Nones; Aldo Scarpa
• Keywords: Association (psychology)

Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups PanNETs, termed T1, T2 T3, distinct patterns methylation. The T1 subgroup was enriched for functional ATRX, DAXX MEN1 wild-type genotypes. contained mutations in recurrent chromosomal losses half genome no association between regions loss levels. were larger had lower MGMT gene body, which showed positive correlation expression. T3 harboured chromosome 11, grade G1 histological parameters better prognosis. Our results suggest a role both driving tumorigenesis potentially stratifying prognosis PanNETs.