AdipoR agonist increases insulin sensitivity and exercise endurance in AdipoR-humanized mice

• DOI: 10.1038/s42003-020-01579-9
• Publication Date: 2021-01-08T11:19:34Z
• Authors: Masato Iwabu; Miki Okada-Iwabu; Hiroaki Tanabe; Nozomi Ohuchi; Keiko Miyata; Toshiko Kobori; Sara Odawara; Yuri Kadowaki; Shigeyuki Yokoyama; Toshimasa Yamauchi; Takashi Kadowaki
• Keywords: Adiponectin receptor 1

Abstract Adiponectin receptors, AdipoR1 and AdipoR2 exert anti-diabetic effects. Although muscle-specific disruption of has been shown to result in decreased insulin sensitivity exercise endurance, it remains be determined whether upregulation could reverse them obese diabetic mice. Here, we show that expression human increased levels genes involved mitochondrial biogenesis oxidative stress-detoxification almost the same extents as treadmill exercise, concomitantly endurance Moreover, created AdipoR-humanized mice which express muscle AdipoR1·R2 double-knockout Most importantly, small-molecule AdipoR agonist AdipoRon its beneficial effects via AdipoR, This study suggests skeletal exercise-mimetics, AdipoR1.