Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium

• DOI: 10.1038/s42003-021-02045-w
• Publication Date: 2021-05-05T10:07:04Z
• Authors: Lauren E. Carter; David P. Cook; Curtis W. McCloskey; Melanie A. Grondin; David A. Landry; Tiffany Dang; Olga Collins; Lisa F. Gamwell; Holly A. Dempster; Barbara C. Vander...
• Keywords: SNAI1

Abstract The ovarian surface epithelium (OSE) is a monolayer of epithelial cells surrounding the ovary that ruptures during each ovulation to allow release oocyte. This wound quickly repaired, but mechanisms promoting repair are poorly understood. contribution tissue-resident stem in homeostasis several tissues widely accepted, their involvement OSE unclear. We show traits associated with can be increased following exposure cytokine TGFB1, overexpression transcription factor Snai1 , or deletion Brca1 . find stemness often linked mesenchymal-associated gene expression and higher activation ERK signalling, not consistently dependent on activation. Expression profiles these populations extremely context specific, suggesting may single, distinct population, rather heterogeneous cell state emerge from diverse environmental cues. These findings support require for long-term maintenance, instead achieve this through transient dedifferentiation into stem-like state.