Association between polygenic propensity for psychiatric disorders and nutrient intake

• DOI: 10.1038/s42003-021-02469-4
• Publication Date: 2021-08-26T16:02:31Z
• Authors: Avina K. Hunjan; Christopher Hübel; Yuhao Lin; Thalia C. Eley; Gerome Breen
• Keywords: Polygenic risk score; Association (psychology); Alcohol use disorder

Abstract Despite the observed associations between psychiatric disorders and nutrient intake, genetic studies are limited. We examined whether polygenic scores for associated with intake in UK Biobank ( N = 163,619) using linear mixed models. found attention-deficit/hyperactivity disorder, bipolar schizophrenia showed highest number of associations, while a score autism spectrum disorder no association. The relatively weaker obsessive-compulsive greatest effect sizes suggesting its association diet traits may become more apparent larger genome-wide analyses. A higher alcohol dependence was individuals persistent thinness reported their food to weigh less, both independent socioeconomic status. Our findings suggest that propensity is dietary behaviour. Note, self-reported must therefore be interpreted mindfully.