AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice

• DOI: 10.1038/s42003-021-02837-0
• Publication Date: 2021-11-18T11:03:47Z
• Authors: Madelene Ericsson; Pär Steneberg; Rakel Nyrén; Helena Edlund
• Keywords: Hyperinsulinemia; Physical exercise

Abstract Age is associated with progressively impaired, metabolic, cardiac and vascular function, as well reduced work/exercise capacity, mobility, hence quality of life. Exercise exhibit positive effects on age-related dysfunctions diseases. However, for a variety reasons many aged individuals are unable to engage in regular physical activity, making the development pharmacological treatments that mimics beneficial exercise highly desirable. Here we show pan-AMPK activator O304, which tolerated humans, prevented reverted age-associated hyperinsulinemia insulin resistance, improved function capacity mice. These results provide preclinical evidence O304 exercise. Thus, an mimetic clinical development, AMPK holds great potential mitigate metabolic dysfunction, improve life individuals.