Time-resolved structure-function coupling in brain networks

• DOI: 10.1038/s42003-022-03466-x
• Publication Date: 2022-06-02T10:07:35Z
• Authors: Zhen-Qi Liu; Bertha Vázquez-Ro...; R. Nathan Spreng; Boris C. Bernhardt; Richard F. Betzel; Bratislav Misic
• Keywords: Cerebral Cortex; 0301 basic medicine; Brain Mapping; 03 medical and health sciences; QH301-705.5; Brain; Biology (General); Magnetic Resonance Imaging; Article; Frontal Lobe

AbstractThe relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we study structure-function coupling from a dynamic perspective, and show that it is regionally heterogeneous. We use a temporal unwrapping procedure to identify moment-to-moment co-fluctuations in neural activity, and reconstruct time-resolved structure-function coupling patterns. We find that patterns of dynamic structure-function coupling are region-specific. We observe stable coupling in unimodal and transmodal cortex, and dynamic coupling in intermediate regions, particularly in insular cortex (salience network) and frontal eye fields (dorsal attention network). Finally, we show that the variability of a region’s structure-function coupling is related to the distribution of its connection lengths. Collectively, our findings provide a way to study structure-function relationships from a dynamic perspective.