Metastable oscillatory modes emerge from synchronization in the brain spacetime connectome

• DOI: 10.1038/s42005-022-00950-y
• Publication Date: 2022-07-15T04:02:57Z
• Authors: Joana Cabral; Francesca Castaldo; Jakub Vohryzek; Vladimir Litvak; Christian Bick; Renaud Lambiotte; Karl Friston; Morten L. Kringel...; Gustavo Deco
• Keywords: Magnetoencephalography; Metastability

Abstract A rich repertoire of oscillatory signals is detected from human brains with electro- and magnetoencephalography (EEG/MEG). However, the principles underwriting coherent oscillations their link neural activity remain under debate. Here, we revisit mechanistic hypothesis that transient brain rhythms are a signature metastable synchronization, occurring at reduced collective frequencies due to delays between areas. We consider system damped oscillators in presence background noise – approximating short-lived gamma-frequency generated within neuronal circuits coupled according diffusion weighted tractography Varying global coupling strength conduction speed, identify critical regime where spatially spectrally resolved modes (MOMs) emerge sub-gamma frequencies, MEG power spectra 89 healthy individuals rest. Further, demonstrate frequency, duration, scale MOMs as well frequency-specific envelope functional connectivity can be controlled by parameters, while connectome structure remains unchanged. Grounded physics delay-coupled oscillators, these numerical analyses how interactions locally fast spacetime lead emergence organized space time.