Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

• DOI: 10.1038/sj.bjc.6605058
• Publication Date: 2009-04-28
• Authors: Nilsson, R.J.A.; Skog, J.; Nordstrand, A.; Baranov, V.; Mincheva-Nilsson, L.; Breakefield, X.O.; Widmark, A.; J Nilsson; J Skog; A Nordstrand; V Baranov; L Mincheva-Nilsson; X O Breakefield; A Widmark; Jonas Nilsson; Johan Skog; Annika Nordstrand; Vladimir Baranov; Lucia Mincheva‐Ni...; Xandra O. Breakef...; Anders Widmark
• Keywords: Biomarker Discovery; Cancer Biomarkers; TMPRSS2; Male; 0301 basic medicine; Oncogene Proteins, Fusion; Short Communication; Prostatic Neoplasms; Urinalysis; Exosomes; 6. Clean water; 3. Good health; 03 medical and health sciences; Antigens, Neoplasm; Biomarkers, Tumor; Humans; RNA, Messenger

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients' status.