Multifunctional CD4 T Cell Responses in Patients with Active Tuberculosis

• DOI: 10.1038/srep00216
• Publication Date: 2012-01-10T01:13:20Z
• Authors: Zhengang Qiu; Mingxia Zhang; Yuzhen Zhu; Feiqun Zheng; Puxuan Lu; Haiying Liu; Michael W. Graner; Boping Zhou; Xinchun Chen
• Keywords: Ionomycin

The roles of multifunctional CD4 T cells in human tuberculosis are not well defined. In this study, we found that patients with had decreased PMA/ionomycin stimulated and increased Mycobacterium antigen-specific cells, when compared to individuals latent infection healthy controls. IFN-γ+IL-2+TNF-α+ cell responses were smear-positive those smear-negative tuberculosis. percentage smear positive negatively correlated the grade sputum Acid-Fast Bacilli high-resolution computed tomography score. Therefore, our findings argue against notion Th1 peripheral blood can serve as correlates protective immunity tuberculosis; they suggest decrease may be applied for clinical diagnosis active