STING Mediates Neuronal Innate Immune Response Following Japanese Encephalitis Virus Infection

• DOI: 10.1038/srep00347
• Publication Date: 2012-04-02T10:23:59Z
• Authors: Arshed Nazmi; Rupanjan Mukhopad...; Kallol Dutta; Anirban Basu
• Keywords: Sting; Viral encephalitis; Interferon type I; RIG-I; Flavivirus

Flavivirus-mediated inflammation causes neuronal death, but whether the infected neurons can evoke an innate immune response to elicit their own protection, is unknown. In earlier study we have shown that RIG-I, play a significant role in inducing production and release of molecules are related inflammation. this study, using cell line, show RIG-I acts with STING concerted manner following its interaction Japanese encephalitis viral RNA induce type 1 interferon response. Knock-down showed expressions various inflammatory signaling were down-regulated along increased intracellular load. Alternatively, over-expressing decreased Our results indicate at sub-cellular level, between pattern recognition receptor adapter molecule STING, major contributor immunological responses involving interferons JEV infections.