Viability of Long-Term Gene Therapy in the Cochlea

• DOI: 10.1038/srep04733
• Publication Date: 2014-04-22T09:09:54Z
• Authors: Patrick J. Atkinson; Andrew K. Wise; Brianna O. Flynn; Bryony A. Nayagam; Rachael T. Richar...
• Keywords: Spiral ganglion; Neurotrophin-3

Gene therapy has been investigated as a way to introduce variety of genes treat neurological disorders. An important clinical consideration is its long-term effectiveness. This research aims study the expression and effectiveness gene in promoting spiral ganglion neuron survival after deafness. Adenoviral vectors modified express brain derived neurotrophic factor or neurotrophin-3 were unilaterally injected into guinea pig cochlea one week post ototoxic deafening. After six months, persistence significantly greater neuronal neurotrophin-treated cochleae compared contralateral observed. The observed indicates that potentially viable; however degeneration transduced cells result original insult may limit With further aimed at transducing stable cochlear cells, be an efficacious neurotrophins promote hearing loss.