RNA-Seq-based transcriptome analysis of methicillin-resistant Staphylococcus aureus biofilm inhibition by ursolic acid and resveratrol

• DOI: 10.1038/srep05467
• Publication Date: 2014-06-27T09:05:28Z
• Authors: Nan Qin; Xiaojuan Tan; Yinming Jiao; Lin Liu; Wangsheng Zhao; Shuang Yang; Aiqun Jia
• Keywords: Ursolic acid

Bacterial biofilms are particularly problematic since they become resistant to most available antibiotics. Hence, novel potential antagonists inhibit biofilm formation urgent. Here the influences of two natural products, ursolic acid and resveratrol, on clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate were investigated using RNA-seq differentially expressed genes analyzed Cuffdiff. The results showed that inhibition may reduce amino acids metabolism adhesins expression resveratrol disturb quorum sensing (QS) synthesis surface proteins capsular polysaccharides. In addition, transcriptome analysis combination with vancomycin established revealed would related QS, secreted These findings suggest could be useful adjunct therapies for treatment MRSA biofilm-involved infections.