Non-Polio Enteroviruses from Acute Flaccid Paralysis Surveillance in Shandong Province, China, 1988–2013

• DOI: 10.1038/srep06167
• Publication Date: 2014-08-22T09:04:25Z
• Authors: Zexin Tao; Haiyan Wang; Yao Liu; Yan Li; Ping Jiang; Guifang Liu; Xiaojuan Lin; Manshi Li; Suting Wang; Feng Ji; Lei Feng; Ping Xiong; Yan Zhang; Yi Feng; Qingying Fan; He Yang; Jing Yang; Peng Chen; Wenfeng Li; Aiqiang Xu; Lizhi Song
• Keywords: Acute flaccid paralysis; Echovirus; Coxsackievirus

Enteroviruses (EVs) are important human pathogens associated with various clinical syndromes. This study represents an overview of non-polio enteroviruses (NPEVs) isolated from acute flaccid paralysis (AFP) surveillance in Shandong Province, China 1988 to 2013. Altogether 792 and 170 NPEV isolates were stool specimens 9263 AFP cases 1059 contacts, respectively. Complete VP1 sequencing typing on all 962 revealed 53 types which echovirus (E) 6 (7.6%), E14 E11 (7.4%), coxsackievirus (CV) B3 E25 (5.6%), CVB5 (4.9%), E7 (4.5%) EV-A71 (4.4%) the eight most commonly reported serotypes. Distinct summer–fall seasonality was observed, June–October accounting for 79.3% isolation known month specimen collection. Increase CVA—the predominant hand, foot mouth disease—was observed recent years. Sequence analysis coding region E6 suggested strains had great genetic divergence other countries. The results described this provide valuable information circulation emergence different EV context limited China.