Intravoxel incoherent motion diffusion-weighted MR imaging of gliomas: efficacy in preoperative grading

• DOI: 10.1038/srep07208
• Publication Date: 2014-12-01T10:13:31Z
• Authors: Yu-Chuan Hu; Lin-Feng Yan; Lang Wu; Pang Du; Bao-Ying Chen; Liang Wang; Shu-Mei Wang; Yu Han; Qiang Tian; Ying Yu; Tian-Yong Xu; Wen Wang; Guang-Bin Cui
• Keywords: Intravoxel incoherent motion; Grading (engineering)

The preoperative grading of gliomas, which is critical for guiding therapeutic strategies, remains unsatisfactory. We aimed to retrospectively assess the efficacy intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in gliomas. Forty-two newly diagnosed glioma patients underwent conventional MR imaging, DWI and contrast-enhanced imaging. Parameters apparent diffusion coefficient (ADC), slow (D), fast (D*) fraction ADC (f) were generated. They tested differences between low- high-grade gliomas based on one-way ANOVA. Receiver-operating characteristic (ROC) analyses conducted determine optimal thresholds as well sensitivity specificity grading. ADC, D f higher low-grade whereas D* tended be lower (all P<0.05). AUC, sensitivity, cutoff value, respectively, differentiating from high- follows: 0.926, 100%, 82.8% 0.7 × 10−3 mm2/sec; D, 0.942, 92.3%, 86.2% 0.623 f, 0.902, 35.3%; D*, 0.798, 79.3%, 84.6% 0.303 mm2/sec. IVIM demonstrates